Berberine HCL Powder: Your Trusted GMP-Certified Bulk Supplier

As a leading Berberine HCL supplier, OcleanNutra provides premium-grade, high-purity Berberine Hydrochloride powder in bulk quantities. Our product is rigorously tested to meet global compliance standards, including GMP and USP, ensuring you receive a safe, effective, and reliable raw material for your dietary supplement formulations. Partner with us for a consistent supply of Berberine HCL 97% backed by expert technical support and comprehensive documentation.

What is Berberine HCL?

Berberine Hydrochloride, commonly referred to in the industry as Berberine HCL, is the stable and bioavailable salt form of Berberine—a potent, naturally occurring isoquinoline alkaloid. This conversion into its hydrochloride form is a critical pharmaceutical processing step that significantly enhances the compound's stability, solubility, and ultimately, its absorption within the human body compared to its base alkaloid form. For manufacturers seeking a reliable and effective raw material for nutraceuticals, this optimized properties make Berberine HCL powder the unequivocal standard for high-quality supplement production.

In its pure state, this compound presents as a vibrant, yellow-colored fine powder, which is a visual indicator of its high purity and potency. The intensity of the color is often correlated with the quality of the extraction and purification processes. As a leading Berberine HCL manufacturer, we subject every batch to rigorous HPLC testing to ensure the assay purity meets our stringent specifications, typically at 98% or higher, guaranteeing that you receive a consistent and potent ingredient for your formulations.

From a functional perspective, Berberine HCL's primary mechanism of action, which underpins its widespread use in metabolic health supplements, is its ability to activate the intracellular enzyme AMPK (AMP-activated protein kinase). This enzyme acts as a master regulator of cellular metabolism. Its role is so fundamental that Berberine HCL is not just another herbal extract; it is a well-researched, science-backed active ingredient that provides a solid foundation for your blood sugar and weight management support formulations, ensuring your end products deliver tangible value to consumers.

Sources of Berberine

Berberine is a naturally occurring benzylisoquinoline alkaloid found in the roots, rhizomes, and stem bark of various plants used in traditional medicine systems across Asia and North America. Unlike many modern pharmaceutical compounds, berberine is not typically synthesized artificially on a commercial scale due to the complexity of its molecular structure and the economic viability of botanical extraction.

The primary botanical sources for commercial berberine extraction include:

Coptis chinensis (Chinese Goldthread): Particularly valued for its high berberine content in the rhizomes
Berberis vulgaris (Barberry) and related Berberis species: The stem bark contains significant concentrations
Hydrastis canadensis (Goldenseal): The roots and rhizomes are used for extraction
Phellodendron amurense (Amur Corktree): The bark serves as another important source

The berberine extracted from these plants undergoes a conversion process to form the more stable and bioavailable hydrochloride salt - Berberine Hydrochloride (Berberine HCL). This pharmaceutical processing step enhances the compound's properties for use in nutraceutical and pharmaceutical applications while maintaining the intrinsic biological activity of the natural alkaloid.

The specific plant source, harvesting practices, and extraction methodology can influence the phytochemical profile of the final Berberine HCL material, making consistent sourcing and quality control essential parameters for manufacturing standardized bulk ingredients.

The Efficacy and Mechanism of Berberine HCL

Berberine HCL stands out in the nutraceutical industry due to its well-researched mechanism of action. It primarily works by activating AMP-activated protein kinase (AMPK), a crucial cellular enzyme that functions as the body's metabolic master switch. This targeted mechanism is responsible for its wide-ranging health benefits, making Berberine HCL powder a powerful ingredient for evidence-based formulations.

Key health benefits supported by research include:

Metabolic Health: It is highly sought after for blood sugar support formulas and weight management supplements by promoting healthy glucose metabolism and insulin sensitivity.
Cardiovascular Support: It contributes to cardiovascular wellness by supporting healthy cholesterol levels and lipid metabolism.
Gut Health: It promotes a balanced gut microbiome and supports overall digestive function.

Ready to formulate with this proven ingredient? Contact us for formulation support and a competitive bulk quote for Berberine HCL.

Application Areas and Formulation Suggestions

The versatility of Berberine HCL powder makes it a valuable ingredient across various product formats. Its applications include:

Dietary Supplements: Hard-shell capsules, tablets, and softgels are the most common delivery forms for Berberine for blood sugar support.
Functional Foods and Beverages: It can be incorporated into powdered drink mixes and health tonics (note: its bitter taste requires effective flavor masking).
Sports Nutrition: Integrated into formulas aimed at weight management.

Looking for a trusted partner for your next product launch? Let's discuss your application and our custom formulation options.

How is Berberine HCL Produced?

The production of high-purity Berberine HCL involves a sophisticated process of extraction, purification, and conversion. It begins with the harvested plant material undergoing a solvent extraction to isolate the native Berberine. This extract then undergoes multiple purification steps, including crystallization, to remove impurities. Finally, it is converted into the stable hydrochloride salt form. As a reliable Berberine HCL factory, we control this process under strict GMP conditions to ensure the final Berberine hydrochloride powder meets our rigorous Specification Sheet for purity and potency.

Product Specifications: Berberine HCL Powder

For B2B partners requiring detailed technical documentation. A comprehensive, batch-specific Certificate of Analysis (COA) will be provided promptly upon request.

Parameter	Specification	Test Method
Identity
Product Name	Berberine Hydrochloride	-
CAS No.	633-65-8	-
Appearance	Bright Yellow Fine Powder	Visual Inspection
Key Specifications
Assay (HPLC)	≥ 98%	HPLC
Loss on Drying	≤ 5.0%	USP <731>
Residue on Ignition	≤ 0.1%	USP <733>
Particle Size	80-100 Mesh	Laser Diffraction
Solubility	Soluble in DMSO, Slightly Soluble in Water	Solubility Test
Safety & Quality
Heavy Metals
- Lead (Pb)	≤ 3.0 mg/kg	ICP-MS
- Arsenic (As)	≤ 2.0 mg/kg	ICP-MS
- Cadmium (Cd)	≤ 1.0 mg/kg	ICP-MS
- Mercury (Hg)	≤ 0.1 mg/kg	ICP-MS
Total Plate Count	≤ 1000 CFU/g	USP <61>
Yeast & Mold	≤ 100 CFU/g	USP <61>
E. Coli	Negative	USP <62>
Salmonella	Negative	USP <62>
Certifications	ISO 9001, GMP (Certificates available upon request)	Audit Certification

Note: The specifications above define our standard Berberine HCL product profile. We also provide customization options—such as adjustments to purity levels and particle size distribution—to meet specific formulation requirements. Contact us to request the full Certificate of Analysis (COA) for detailed, batch-specific data and supporting compliance documentation.

Packaging, Services & Inquiry

Minimum Order Quantity (MOQ): 1 kg
Free Sample: Available (10-20g/bag) for qualified businesses.
Custom Services: Full support for OEM, ODM, Private Label, and Contract Manufacturing.
Standard Packaging: 1 kg/bag, 25 kg/drum. Custom packaging available.
Shelf Life: 24 months in a cool, dry place away from light.

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Side Effects and Safety Profile

Berberine HCL is generally safe for consumption when used appropriately. Common side effects are typically mild and gastrointestinal in nature, such as mild discomfort, which often subside as the body adjusts. It is always recommended that finished product manufacturers advise end-users to consult with a healthcare professional before starting any new supplement, especially those who are pregnant, nursing, or on medication. Our role as your GMP certified Berberine HCL supplier is to provide the pure, consistent raw material that allows you to formulate with confidence.

FAQs

What is the difference between Berberine and Berberine HCL?

Berberine is the base alkaloid, while Berberine HCL is the stabilized salt form with enhanced bioavailability, making it the preferred choice for high-quality supplement manufacturing.

Can I buy Berberine HCL in bulk from you?

Absolutely. We specialize in supplying bulk Berberine hydrochloride to manufacturers and brands worldwide. Contact our sales team for a custom quote.

What is the typical lead time for Berberine HCL powder?

For standard orders, we maintain strategic inventory to ensure delivery within 5-10 business days. Larger custom-quantity orders may require additional production time; all lead times are communicated transparently during the order confirmation process.

Is your Berberine HCL non-GMO and gluten-free?

Yes, our Berberine HCL powder is certified non-GMO and gluten-free, meeting the demands of the discerning health market. Full documentation is available upon request.

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