Creatine Monohydrate Powder: A Premium Raw Material for Sports Nutrition

As a leading Creatine Monohydrate supplier, OcleanNutra provides high-purity, micronized Creatine powder to support global brands in creating effective sports supplements. This comprehensive guide details the science, benefits, and specifications of this proven performance enhancer, designed to help you make an informed sourcing decision for your bulk Creatine Monohydrate needs.

What is Creatine Monohydrate Powder? A Chemical and Functional Definition

Creatine Monohydrate (C₄H₉N₃O₂·H₂O) is the monohydrate form of creatine, a nitrogenous guanidino compound naturally synthesized in the liver and kidneys. Its molecular structure consists of a creatine molecule associated with one molecule of water, forming a stable, crystalline complex. This specific hydrate form is renowned for its optimal stability and bioavailability, making it the unequivocal gold standard in the supplement industry.

For sports nutrition brands and supplement manufacturers, sourcing pure creatine monohydrate is paramount. Its consistent chemical profile ensures predictable outcomes in product formulation, efficacy, and consumer satisfaction.

Sources and Synthetic Production: Ensuring Purity and Scale

While trace amounts are found in animal tissue (e.g., beef, salmon), commercial-scale production for health supplements relies exclusively on sophisticated chemical synthesis. This method guarantees a contaminant-free, vegan-compliant, and scalable supply of bulk creatine monohydrate.

The industry-standard synthesis involves a controlled reaction between sarcosine and cyanamide. This process, conducted in a reactor under specific temperature and pH conditions, yields creatine crystals of high purity.

The Efficacy of Creatine Monohydrate: A Mechanisms-Based Analysis

The ergogenic benefits of creatine monohydrate are not anecdotal; they are grounded in well-established biochemistry, primarily within the phosphagen energy system.

ATP Resynthesis: Creatine is phosphorylated to Phosphocreatine (PCr) within muscle cells. PCr acts as a readily available phosphate donor to rapidly regenerate Adenosine Triphosphate (ATP) from Adenosine Diphosphate (ADP) during the initial seconds of high-intensity exercise. This directly translates to improved strength, power, and sprint performance.
Cell Volumization: Creatine uptake draws water into muscle cells, increasing cell volume. This anabolic signal promotes protein synthesis and glycogen storage, contributing to gains in lean body mass.
Buffering Capacity: Emerging evidence suggests creatine may help buffer lactic acid accumulation, delaying the onset of muscular fatigue and improving recovery times.
Neurological Potential: The brain's high energy demands make it another potential beneficiary, with research exploring creatine's role in cognitive function and neuroprotection.

The efficacy is directly tied to purity. Our pharmaceutical grade creatine ensures your end-users receive the full, researched benefits without interference from impurities.

How Do We Produce High-Quality Creatine? A Glimpse into Our Process

As a dedicated creatine monohydrate manufacturer, our differentiation lies in our process rigor and quality control, which far exceeds basic monograph requirements.

1.Synthesis & Crystallization: The reaction of sarcosine and cyanamide is meticulously controlled. The subsequent crystallization process is engineered to produce a consistent crystal habit and particle size distribution (80-200 mesh, customizable), which is critical for blend uniformity and dissolution rates in your final product.
2.Purification & Washing: The crude creatine undergoes multiple washing cycles with high-purity solvents and water to remove by-products like creatinine, dicyandiamide, and heavy metals. This stage is crucial for achieving our ≥99.5% purity specification.
3.Drying & Milling: The purified crystals are dried in a fluidized bed dryer under low-temperature, controlled humidity conditions to preserve the monohydrate structure and prevent degradation. Precise milling then achieves the target mesh size.
4.Quality Assurance: Every batch is tested in our in-house QC laboratory against a comprehensive specification sheet. We employ techniques like HPLC for assay, Karl Fischer for moisture, and ICP-MS for heavy metals. As a GMP certified creatine supplier, full traceability and documentation are maintained.

Product Specifications: Creatine Monohydrate Powder

For B2B partners requiring detailed technical documentation. A comprehensive, batch-specific Certificate of Analysis (COA) will be provided promptly upon request.

Parameter	Specification	Test Method
Identity
Product Name	Creatine Monohydrate	-
CAS No.	6020-87-7	-
Molecular Formula	C₄H₉N₃O₂·H₂O	-
Appearance	White, Free-Flowing Crystalline Powder	Visual Inspection
Key Specifications
Assay (Creatine)	≥ 99%	HPLC
Loss on Drying	9.0% - 12.0%	Karl Fischer / Gravimetric
Creatinine	≤ 50 mg/kg	HPLC
Mesh Size	80-200 Mesh	Laser Diffraction
Safety & Quality
Heavy Metals
- Lead (Pb)	≤ 3.0 mg/kg	ICP-MS
- Arsenic (As)	≤ 3.0 mg/kg	ICP-MS
- Cadmium (Cd)	≤ 1.0 mg/kg	ICP-MS
- Mercury (Hg)	≤ 0.1 mg/kg	ICP-MS
Total Plate Count	≤ 1000 CFU/g	USP <61>
Yeast & Mold	≤ 100 CFU/g	USP <61>
E. Coli	Negative	USP <62>
Salmonella	Negative	USP <62>
Certifications	ISO 9001, GMP (Certificates available upon request)	Audit Certification

Note: The specifications above define our standard Creatine Monohydrate product profile. We also provide customization options—such as adjustments to particle size distribution and packaging—to meet specific formulation requirements. Contact us to request the full Certificate of Analysis (COA) for detailed, batch-specific data and supporting compliance documentation.

Packaging, Services & Inquiry

Minimum Order Quantity (MOQ): 1 kg
Free Sample: Available (10-20g/bag) for qualified businesses.
Custom Services: Full support for OEM, ODM, Private Label, and Contract Manufacturing.
Standard Packaging: 1 kg/bag, 25 kg/drum. Custom packaging available.
Shelf Life: 24 months in a cool, dry place away from light.

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Side Effects, Safety, and Regulatory Status

Creatine Monohydrate has an exceptional safety profile, confirmed by numerous meta-analyses and regulatory bodies worldwide. It is generally recognized as safe (GRAS) for use in dietary supplements.

Water Retention: Initial intracellular water retention is common and is a sign of muscle saturation, not a negative side effect.
Gastrointestinal Distress: This is typically dose-dependent and can be mitigated by using a micronized creatine monohydrate with superior solubility, or by splitting doses. It is often linked to impure products.
Kidney Function: No credible evidence links creatine supplementation with renal damage in healthy individuals.

Sourcing from a trusted wholesale creatine monohydrate supplier like OcleanNutra, who provides full transparency and CoAs, is the best risk mitigation strategy for your brand.

FAQs

What is the difference between your creatine monohydrate and other forms like HCL?

Creatine Monohydrate is the gold standard, with the most extensive research backing its efficacy and safety. While other forms like Creatine HCL may have improved solubility, monohydrate remains the most cost-effective and proven choice for bulk supplement production.

Are you a certified GMP certified creatine supplier?

Yes, OcleanNutra is a GMP certified creatine supplier. Our manufacturing facilities and processes adhere to strict Good Manufacturing Practice (GMP) guidelines, ensuring the highest level of quality and traceability for our B2B clients.

Do you offer private label creatine monohydrate services?

Absolutely. We are a leading private label creatine monohydrate partner. We can supply bulk powder for your branding needs, offering custom packaging solutions to help your product stand out in the market.

What is the typical lead time for a wholesale creatine monohydrate order?

As a reliable wholesale creatine monohydrate supplier, we maintain strategic stock. we maintain an efficient lead time of 5 to 10 business days.

Is your creatine monohydrate suitable for vegan supplements?

Yes, our pure creatine monohydrate is synthetically produced, making it 100% suitable for vegan and vegetarian health supplements. It's a key ingredient for brands targeting the plant-based market.

Why should I choose you as my bulk creatine powder supplier?

We distinguish ourselves through an unwavering commitment to quality. We are not just a trader but a creatine monohydrate manufacturer with control over the entire production process. This allows us to guarantee purity, provide competitive bulk pricing, and offer technical support to our partners.

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