PQQ Pyrroloquinoline Quinone: A Premium Raw Material for Innovative Supplement Formulations

As a leading PQQ Pyrroloquinoline Quinone supplier, OcleanNutra specializes in providing high-purity PQQ powder in bulk to manufacturers and wholesalers worldwide. Our bulk PQQ is manufactured in cGMP-certified facilities and comes with comprehensive documentation, including a Certificate of Analysis (COA), ensuring it meets the stringent quality standards required for private label and OEM supplement production. This page details everything B2B buyers need to know about our Pyrroloquinoline Quinone bulk offerings, from specifications and benefits to production and partnership opportunities.

What is PQQ (Pyrroloquinoline Quinone)?

PQQ (Pyrroloquinoline Quinone) is a powerful, vitamin-like compound that acts as a key antioxidant and cofactor in cellular energy metabolism. Unlike many other antioxidants, PQQ has the unique ability to create and protect new mitochondria—the powerhouses of the cell. This makes it a highly sought-after ingredient in the nutraceutical industry for formulating supplements aimed at supporting energy production, cognitive health, and overall vitality.

Natural Sources of PQQ

While PQQ is found in trace amounts in certain foods like kiwifruit, spinach, and green tea, obtaining sufficient quantities for therapeutic supplement formulations through diet alone is impractical. This is why sourcing high-quality, pure PQQ powder from a reliable bulk supplier is crucial for brands that want to deliver effective products to their customers.

The Efficacy and Key Benefits of PQQ

The growing demand for PQQ is driven by its extensive research-backed benefits, which form the basis of many compelling product claims.

Cellular Energy & Mitochondrial Support: PQQ is renowned for its role in energy production by supporting mitochondrial biogenesis.
Cognitive Function & Neuroprotection: As a potent nootropic, PQQ helps protect brain cells from oxidative stress and supports memory and cognitive health.
Powerful Antioxidant Protection: PQQ offers superior antioxidant benefits, neutralizing free radicals more effectively than many common antioxidants.
Heart Health & Metabolic Support: Research indicates PQQ can support cardiovascular health and healthy metabolic function.

These diverse benefits of PQQ make it an ideal ingredient for formulations targeting energy, anti-aging, and cognitive health supplements.

How We Produce High-Quality PQQ Powder?

At OcleanNutra, our status as a leading cGMP manufacturer of PQQ powder is rooted in our mastery of advanced microbial fermentation technology. This bio-based production method is not only scalable and sustainable but also yields a product of superior purity and biological activity, far exceeding what can be achieved through traditional synthetic routes.

Our production process is a multi-stage, rigorously controlled operation:

1. Precision Strain Selection and Development:

The foundation of our high-quality PQQ lies in our proprietary microbial strains. We utilize meticulously selected and optimized non-pathogenic bacteria that act as highly efficient biological factories for Pyrroloquinoline Quinone production. Our ongoing R&D focuses on strain improvement to maximize yield and purity, ensuring a cost-effective and reliable supply for our bulk PQQ clients.

2. State-of-the-Art Fermentation Process:

This is the core of our operation. In our computer-controlled, large-scale fermenters, we create an ideal environment for our microbial strains to thrive and produce PQQ. Key parameters such as temperature, pH, dissolved oxygen, and nutrient feed are continuously monitored and adjusted in real-time. This precise control over the fermentation process guarantees batch-to-batch consistency, operational reproducibility, and maximizes the efficiency of PQQ synthesis.

3. Downstream Processing & Purification:

Post-fermentation, the crude PQQ undergoes a series of sophisticated downstream processing steps to isolate and refine the compound to its highest potential.

Separation & Extraction: We employ advanced techniques like multi-stage membrane filtration and centrifugation to separate the microbial biomass from the PQQ-rich broth.
Multi-Step Chromatographic Purification: The extract is then processed through specialized chromatographic columns. This critical step is what allows us to achieve a purity of ≥99.0%, effectively removing process-related impurities, residual nutrients, and endotoxins.
Crystallization & Drying: The purified PQQ solution is carefully crystallized and then dried using spray-drying or freeze-drying technology to obtain a stable, free-flowing pure PQQ powder with optimal shelf-life.

4. Uncompromising Quality Control & Analytical Verification:

Quality is not just tested; it is built into every step of our production process. Our in-house quality control laboratory is equipped with cutting-edge analytical instruments, including High-Performance Liquid Chromatography (HPLC) for precise potency assay and Mass Spectrometry for identity confirmation. Every single batch of our PQQ powder is tested against stringent in-house specifications and international standards for:

Potency and Purity (HPLC Assay)
Residual Solvents and Heavy Metals
Microbiological Contaminants (Total Plate Count, Yeast & Mold)
Physical Characteristics (Appearance, Loss on Drying)

This data is comprehensively documented in the Certificate of Analysis (COA) that accompanies every shipment, providing you with full transparency and traceability from our production line to your facility.

By integrating this advanced fermentation technology with a culture of quality excellence, we guarantee a contaminant-free, highly bioavailable PQQ powder that delivers consistent performance in your final supplement formulations. This robust and transparent production process is why global brands trust OcleanNutra as their PQQ supplier.

Product Specifications: PQQ Pyrroloquinoline Quinone

For B2B partners requiring detailed technical documentation. A comprehensive, batch-specific Certificate of Analysis (COA) will be provided promptly upon request.

Parameter	Specification	Test Method
Identity
Product Name	Pyrroloquinoline Quinone (PQQ)	-
CAS No.	72909-34-3	-
Molecular Formula	C₁₄H₆N₂O₈	-
Appearance	Dark Brown to Brownish-Orange, Fine Powder	Visual Inspection
Key Specifications
Assay (Purity)	≥ 98.0%	HPLC
Loss on Drying	≤ 2.0%	USP <731>
Residue on Ignition	≤ 0.2%	USP <281>
Safety & Quality
Heavy Metals
- Lead (Pb)	≤ 3.0 mg/kg	ICP-MS
- Arsenic (As)	≤ 2.0 mg/kg	ICP-MS
- Cadmium (Cd)	≤ 1.0 mg/kg	ICP-MS
- Mercury (Hg)	≤ 0.1 mg/kg	ICP-MS
Total Plate Count	≤ 1000 CFU/g	USP <61>
Yeast & Mold	≤ 100 CFU/g	USP <61>
E. Coli	Negative	USP <62>
Salmonella	Negative	USP <62>
Certifications	ISO 9001, GMP (Certificates available upon request)	Audit Certification

Note: The specifications above define our standard PQQ Pyrroloquinoline Quinone product profile. We also provide customization options—such as adjustments to purity levels and particle size distribution—to meet specific formulation requirements. Contact us to request the full Certificate of Analysis (COA) for detailed, batch-specific data and supporting compliance documentation.

Packaging, Services & Inquiry

Minimum Order Quantity (MOQ): 1 kg
Free Sample: Available (10-20g/bag) for qualified businesses.
Custom Services: Full support for OEM, ODM, Private Label, and Contract Manufacturing.
Standard Packaging: 1 kg/bag, 25 kg/drum. Custom packaging available.
Shelf Life: 24 months in a cool, dry place away from light.

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Safety and Potential Side Effects of PQQ

PQQ is generally recognized as safe (GRAS) when consumed in appropriate doses. Extensive studies have shown a high safety profile with no significant side effects reported. As with any concentrated dietary ingredient, it is essential for our B2B clients to adhere to recommended usage levels in their final product formulations.

FAQs

What is PQQ used for in supplements?

PQQ is primarily used in dietary supplements for its benefits related to energy production, cognitive support, and as a powerful antioxidant. It's a key ingredient in formulas for brain health, energy boosters, and anti-aging products.

What is the difference between PQQ vs CoQ10?

While both are crucial for cellular energy, they function differently. CoQ10 primarily helps in the electron transport chain within mitochondria, whereas PQQ not only acts as an antioxidant but also triggers the creation of new mitochondria. They are often used together in supplements for synergistic benefits.

Do you offer PQQ for private label?

Yes, we are a leading private label and OEM PQQ supplier. We can customize capsules, tablets, or provide the pure powder for your brand. Contact our sales team to discuss your specific requirements.

Can I get a sample and a COA before placing a bulk order?

We are happy to provide samples to qualified B2B clients. The sample will be accompanied by its corresponding Certificate of Analysis (COA) so you can verify our product quality firsthand.

What is the typical lead time for wholesale PQQ orders?

For bulk orders, we maintain an efficient lead time of 5 to 10 business days. Lead times vary based on order quantity and customization, but we prioritize fast delivery for bulk orders.

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